Pesquisa | Secretaria de Estado da Saúde

1.

Cone-shaped HIV-1 capsids are transported through intact nuclear pores.

Zila, Vojtech; Margiotta, Erica; Turonová, Beata; Müller, Thorsten G; Zimmerli, Christian E; Mattei, Simone; Allegretti, Matteo; Börner, Kathleen; Rada, Jona; Müller, Barbara; Lusic, Marina; Kräusslich, Hans-Georg; Beck, Martin.

Cell ; 184(4): 1032-1046.e18, 2021 02 18.

Artigo Inglês | MEDLINE | ID: mdl-33571428

2.

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.

Becker, Jonas; Stanifer, Megan Lynn; Leist, Sarah Rebecca; Stolp, Bettina; Maiakovska, Olena; West, Ande; Wiedtke, Ellen; Börner, Kathleen; Ghanem, Ali; Ambiel, Ina; Tse, Longping Victor; Fackler, Oliver Till; Baric, Ralph Steven; Boulant, Steeve; Grimm, Dirk.

Mol Ther ; 30(5): 2005-2023, 2022 05 04.

Artigo Inglês | MEDLINE | ID: mdl-35038579

3.

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9.

Bubeck, Felix; Hoffmann, Mareike D; Harteveld, Zander; Aschenbrenner, Sabine; Bietz, Andreas; Waldhauer, Max C; Börner, Kathleen; Fakhiri, Julia; Schmelas, Carolin; Dietz, Laura; Grimm, Dirk; Correia, Bruno E; Eils, Roland; Niopek, Dominik.

Nat Methods ; 15(11): 924-927, 2018 11.

Artigo Inglês | MEDLINE | ID: mdl-30377362

4.

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.

Börner, Kathleen; Kienle, Eike; Huang, Lin-Ya; Weinmann, Jonas; Sacher, Anna; Bayer, Philipp; Stüllein, Christian; Fakhiri, Julia; Zimmermann, Laura; Westhaus, Adrian; Beneke, Jürgen; Beil, Nina; Wiedtke, Ellen; Schmelas, Carolin; Miltner, Dominik; Rau, Alexander; Erfle, Holger; Kräusslich, Hans-Georg; Müller, Martin; Agbandje-McKenna, Mavis; Grimm, Dirk.

Mol Ther ; 28(4): 1016-1032, 2020 04 08.

Artigo Inglês | MEDLINE | ID: mdl-32105604

5.

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins.

Hoffmann, Mareike D; Aschenbrenner, Sabine; Grosse, Stefanie; Rapti, Kleopatra; Domenger, Claire; Fakhiri, Julia; Mastel, Manuel; Börner, Kathleen; Eils, Roland; Grimm, Dirk; Niopek, Dominik.

Nucleic Acids Res ; 47(13): e75, 2019 07 26.

Artigo Inglês | MEDLINE | ID: mdl-30982889

6.

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.

Kunze, Christine; Börner, Kathleen; Kienle, Eike; Orschmann, Tanja; Rusha, Ejona; Schneider, Martha; Radivojkov-Blagojevic, Milena; Drukker, Micha; Desbordes, Sabrina; Grimm, Dirk; Brack-Werner, Ruth.

Glia ; 66(2): 413-427, 2018 02.

Artigo Inglês | MEDLINE | ID: mdl-29119608

7.

Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

Grosse, Stefanie; Penaud-Budloo, Magalie; Herrmann, Anne-Kathrin; Börner, Kathleen; Fakhiri, Julia; Laketa, Vibor; Krämer, Chiara; Wiedtke, Ellen; Gunkel, Manuel; Ménard, Lucie; Ayuso, Eduard; Grimm, Dirk.

J Virol ; 91(20)2017 10 15.

Artigo Inglês | MEDLINE | ID: mdl-28768875

8.

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

Cordas Dos Santos, David M; Eilers, Juliane; Sosa Vizcaino, Alfonso; Orlova, Elena; Zimmermann, Martin; Stanulla, Martin; Schrappe, Martin; Börner, Kathleen; Grimm, Dirk; Muckenthaler, Martina U; Kulozik, Andreas E; Kunz, Joachim B.

BMC Cancer ; 18(1): 663, 2018 Jun 18.

Artigo Inglês | MEDLINE | ID: mdl-29914415

9.

T160phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes.

Mueller, Stephanie; Huard, Jérémy; Waldow, Katharina; Huang, Xiaoyun; D'Alessandro, Lorenza A; Bohl, Sebastian; Börner, Kathleen; Grimm, Dirk; Klamt, Steffen; Klingmüller, Ursula; Schilling, Marcel.

Mol Syst Biol ; 11(3): 795, 2015 Mar.

Artigo Inglês | MEDLINE | ID: mdl-26148348

10.

AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.

Hentzschel, Franziska; Hammerschmidt-Kamper, Christiane; Börner, Kathleen; Heiss, Kirsten; Knapp, Bettina; Sattler, Julia M; Kaderali, Lars; Castoldi, Mirco; Bindman, Jay G; Malato, Yann; Willenbring, Holger; Mueller, Ann-Kristin; Grimm, Dirk.

Mol Ther ; 22(12): 2130-2141, 2014 12.

Artigo Inglês | MEDLINE | ID: mdl-25189739

11.

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.

Börner, Kathleen; Niopek, Dominik; Cotugno, Gabriella; Kaldenbach, Michaela; Pankert, Teresa; Willemsen, Joschka; Zhang, Xian; Schürmann, Nina; Mockenhaupt, Stefan; Serva, Andrius; Hiet, Marie-Sophie; Wiedtke, Ellen; Castoldi, Mirco; Starkuviene, Vytaute; Erfle, Holger; Gilbert, Daniel F; Bartenschlager, Ralf; Boutros, Michael; Binder, Marco; Streetz, Konrad; Kräusslich, Hans-Georg; Grimm, Dirk.

Nucleic Acids Res ; 41(21): e199, 2013 Nov.

Artigo Inglês | MEDLINE | ID: mdl-24049077

12.

Evolution of SARS-CoV-2 in the Rhine-Neckar/Heidelberg Region 01/2021 - 07/2023.

Bundschuh, Christian; Weidner, Niklas; Klein, Julian; Rausch, Tobias; Azevedo, Nayara; Telzerow, Anja; Mallm, Jan-Philipp; Kim, Heeyoung; Steiger, Simon; Seufert, Isabelle; Börner, Kathleen; Bauer, Katharina; Hübschmann, Daniel; Jost, Katharina Laurence; Parthé, Sylvia; Schnitzler, Paul; Boutros, Michael; Rippe, Karsten; Müller, Barbara; Bartenschlager, Ralf; Kräusslich, Hans-Georg; Benes, Vladimir.

Infect Genet Evol ; 119: 105577, 2024 Apr.

Artigo Inglês | MEDLINE | ID: mdl-38403035

13.

AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery.

Theuerkauf, Samuel A; Herrera-Carrillo, Elena; John, Fabian; Zinser, Luca J; Molina, Mariano A; Riechert, Vanessa; Thalheimer, Frederic B; Börner, Kathleen; Grimm, Dirk; Chlanda, Petr; Berkhout, Ben; Buchholz, Christian J.

Biomaterials ; 303: 122399, 2023 12.

Artigo Inglês | MEDLINE | ID: mdl-37992599

14.

Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors.

Mann, Anna Marei; Schäfer, Waldemar; Adriouch, Sahil; Börner, Kathleen; Grimm, Dirk; Braren, Ingke; Koch-Nolte, Friedrich.

Methods Mol Biol ; 2510: 129-144, 2022.

Artigo Inglês | MEDLINE | ID: mdl-35776323

15.

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.

Flitsch, Lea Jessica; Börner, Kathleen; Stüllein, Christian; Ziegler, Simon; Sonntag-Buck, Vera; Wiedtke, Ellen; Semkova, Vesselina; Au Yeung, Si Wah Christina; Schlee, Julia; Hajo, Mohamad; Mathews, Mona; Ludwig, Beatrice Stefanie; Kossatz, Susanne; Kessler, Horst; Grimm, Dirk; Brüstle, Oliver.

Sci Rep ; 12(1): 8356, 2022 05 19.

Artigo Inglês | MEDLINE | ID: mdl-35589936

16.

Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice.

Beer, Shelly; Bellovin, David I; Lee, Joyce S; Komatsubara, Kimberly; Wang, Lora S; Koh, Huishan; Börner, Kathleen; Storm, Theresa A; Davis, Corrine R; Kay, Mark A; Felsher, Dean W; Grimm, Dirk.

Mol Ther ; 18(1): 161-70, 2010 Jan.

Artigo Inglês | MEDLINE | ID: mdl-19844192

17.

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8.

Michels, Alexander; Frank, Annika M; Günther, Dorothee M; Mataei, Mehryad; Börner, Kathleen; Grimm, Dirk; Hartmann, Jessica; Buchholz, Christian J.

Mol Ther Methods Clin Dev ; 23: 334-347, 2021 Dec 10.

Artigo Inglês | MEDLINE | ID: mdl-34729380

18.

Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography.

Marichal-Gallardo, Pavel; Börner, Kathleen; Pieler, Michael M; Sonntag-Buck, Vera; Obr, Martin; Bejarano, David; Wolff, Michael W; Kräusslich, Hans-Georg; Reichl, Udo; Grimm, Dirk.

Hum Gene Ther ; 32(17-18): 959-974, 2021 09.

Artigo Inglês | MEDLINE | ID: mdl-33554722

19.

SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP.

Klein, Steffen; Müller, Thorsten G; Khalid, Dina; Sonntag-Buck, Vera; Heuser, Anke-Mareil; Glass, Bärbel; Meurer, Matthias; Morales, Ivonne; Schillak, Angelika; Freistaedter, Andrew; Ambiel, Ina; Winter, Sophie L; Zimmermann, Liv; Naumoska, Tamara; Bubeck, Felix; Kirrmaier, Daniel; Ullrich, Stephanie; Barreto Miranda, Isabel; Anders, Simon; Grimm, Dirk; Schnitzler, Paul; Knop, Michael; Kräusslich, Hans-Georg; Dao Thi, Viet Loan; Börner, Kathleen; Chlanda, Petr.

Viruses ; 12(8)2020 08 07.

Artigo Inglês | MEDLINE | ID: mdl-32784757

20.

Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids.

Herrmann, Anne-Kathrin; Große, Stefanie; Börner, Kathleen; Krämer, Chiara; Wiedtke, Ellen; Gunkel, Manuel; Grimm, Dirk.

Hum Gene Ther ; 30(1): 21-35, 2019 01.

Artigo Inglês | MEDLINE | ID: mdl-29978729

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